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Scientific Record

Scientific Contributions &
Evidence of Work

Conference presentations, publications, and anonymised project work.

Conference Presentations

Global speaking engagements and peer-reviewed abstracts.

Economic Burden of Hemophilia B Patients in the United States
Conference Poster
Article 2022

Economic Burden of Hemophilia B Patients in the United States

Comprehensive analysis of direct and indirect costs associated with Hemophilia B management.

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Health-related quality of life in ulcerative colitis patients treated with tofacitinib
Conference Poster
Article 2022

Health-related quality of life in ulcerative colitis patients treated with tofacitinib

Systematic review and meta-analysis of HRQoL outcomes in UC patients from RCTs.

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Twenty Years of Clinical Trials in Duchenne Muscular Dystrophy
Conference Abstract
Article 2021

Twenty Years of Clinical Trials in Duchenne Muscular Dystrophy

Historical outcome analysis of trial design and regulatory success rates in DMD.

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Cutaneous T-Cell Lymphoma: Patient's Perception and Challenges
Conference Presentation
Article 2020

Cutaneous T-Cell Lymphoma: Patient's Perception and Challenges

Patient-reported outcomes and burden of disease evaluation in T-Cell Lymphoma.

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Financial impact of introducing sc trastuzumab (herceptin) versus iv trastuzumab
Conference Abstract
Article 2017

Financial impact of introducing sc trastuzumab (herceptin) versus iv trastuzumab

Budget impact analysis of subcutaneous versus intravenous administration across KSA hospitals.

View Abstract

Section 02

Publications & Co-Authored Work

Peer-reviewed journals, methodology papers, and systematic literature reviews.

Value in Health (IF: 4.9)

Goyal R., et al.

Applicability of Artificial Intelligence in Targeted Literature Review

Evaluation of AI tools for accelerating and improving the accuracy of targeted literature reviews.

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Value in Health (IF: 4.9)

Goyal R., et al.

Adoption of Artificial Intelligence in Systematic Reviews

Methodological assessment of AI integration within evidence synthesis workflows.

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Value in Health (IF: 4.9)

Goyal R., et al.

Quality Assessment of Systematic Literature Review and Meta-Analysis: Comparison of AMSTAR-2 and ROBIS

Methodological comparison of quality assessment frameworks in evidence synthesis.

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Value in Health (IF: 4.9)

Goyal R., et al.

A Comparison of NOS and ROBINS-I Tools for Quality Assessment of Observational Studies

Evaluation of bias assessment methodologies for real-world and observational data.

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Value in Health (IF: 4.9)

Goyal R., et al.

Possible Applications of Real World Evidence (RWE) in Safety Operations

Strategic framework for utilizing RWE in pharmacovigilance and drug safety monitoring.

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Drug Discovery and Clinical Research (Book Chapter)

Goyal R.

Basic Principles of Pharmacoeconomics and Outcomes Research

Foundational chapter on the principles of pharmacoeconomic evaluation.

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Pharmaceutical Medicine and Translational Clinical Research (Book Chapter)

Goyal R.

Pharmacoeconomics in Healthcare

Comprehensive guide on integrating health economics into translational research.

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Value in Health (IF: 4.9)

Goyal R., et al.

Health Utility Values in Small Cell Lung Cancer: A Literature Review

Systematic identification of health state utility values for SCLC economic modeling.

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Value in Health (IF: 4.9)

Goyal R., et al.

Biomarker testing in non-small cell lung cancer (NSCLC): where we have been, where we are going?

Strategic review of the health economic impact of biomarker-driven treatments in NSCLC.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and Safety Profile of Combined Targeted Therapy Against EGFR and VEGF in Advanced NSCLC

Systematic review and meta-analysis of combination targeted therapies in lung cancer.

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Value in Health (IF: 4.9)

Goyal R., et al.

Impact of treatment adherence on core outcomes in patients with colo-rectal cancer: A systematic review

Analysis correlating medication adherence with long-term survival and economic outcomes.

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Value in Health (IF: 4.9)

Goyal R., et al.

A systematic review of efficacy and safety of mitapivat to treat hemolytic anemia in pyruvate kinase deficiency

Evidence synthesis of targeted therapies for rare hematological disorders.

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Value in Health (IF: 4.9)

Goyal R., et al.

Statins Use and the Risk of Haematological and Non-Haematological Malignancies: A Meta-Analysis

Meta-analysis of 53 observational studies assessing the oncological safety profile of statins.

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Value in Health (IF: 4.9)

Goyal R., et al.

To determine the financial impact of introducing sc rituximab (mabthera) vs. Currently used iv rituximab

Hospital-level economic evaluation of administration routes for monoclonal antibodies.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and Safety of Daridorexant in patients with Insomnia: Systematic review & Meta-analysis

Evidence synthesis of randomized controlled trials for sleep-wake disorder therapies.

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Value in Health (IF: 4.9)

Goyal R., et al.

Comparison of Approved Doses of Lemborexant for Insomnia in Placebo-Controlled Trials

Systematic review and network meta-analysis of dosing efficacy.

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Value in Health (IF: 4.9)

Goyal R., et al.

Economic Burden of Young Onset Parkinson's Disease: A Systematic Literature Review

Evaluation of the direct healthcare costs and productivity loss associated with early-onset Parkinson's.

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Value in Health (IF: 4.9)

Goyal R., et al.

Therapeutic Role of Melatonin in Paediatric Migraine: A Systematic Review and Meta-Analysis

Clinical evidence synthesis assessing alternative prophylactic treatments in pediatric neurology.

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Value in Health (IF: 4.9)

Goyal R., et al.

Comparative efficacy and safety of preventive therapies for neuromyelitis optica

Systematic review and network meta-analysis of disease-modifying therapies.

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Value in Health (IF: 4.9)

Goyal R., et al.

Targeted Literature Review of Health State Utility Values in Neuromyelitis Optica Spectrum Disorder

Identification of utility decrements required for cost-utility analysis in NMOSD.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and safety of brexanolone in the treatment of postpartum depression

Systematic review and meta-analysis of targeted neuroactive steroid therapies.

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Diabetes Research and Clinical Practice (IF: 6.1)

Goyal R., et al.

Clinical and economic outcomes of continuous glucose monitoring system (CGMS) in patients with diabetes mellitus

Systematic literature review evaluating the clinical value and cost-effectiveness of CGMS.

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Value in Health (IF: 4.9)

Goyal R., et al.

Incidence/prevalence, risk factors and complications of type 2 diabetes mellitus in Indian patients

Systematic review and meta-analysis of regional epidemiological data for T2DM.

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Value in Health (IF: 4.9)

Goyal R., et al.

HbA1C Targets for Patients With Type 2 Diabetes: Results of a Systematic Literature Review

Analysis of glycemic control targets and associated long-term macrovascular outcomes.

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Value in Health (IF: 4.9)

Goyal R., et al.

Familial Hypercholesterolemia and Risk of Cardiovascular Disease: A Systematic Literature Review

Meta-analysis of observational studies linking genetic lipid disorders to CV events.

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Value in Health (IF: 4.9)

Goyal R., et al.

Safety and tolerability of bisoprolol compared to atenolol in patients with mild to moderate hypertension

Comparative safety synthesis of beta-blocker therapies in cardiovascular management.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and safety of etelcalcetide in the treatment of secondary hyperparathyroidism in adult patients with chronic kidney disease

Systematic review and meta-analysis for CKD patients undergoing dialysis.

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Value in Health (IF: 4.9)

Goyal R., et al.

Adherence to drug therapy in chronic kidney disease: a systematic review

Evaluation of real-world compliance rates and health outcomes in nephrology.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and safety of golimumab in pediatric ulcerative colitis: A Systematic literature review

Evidence synthesis of biologic therapies in pediatric gastroenterology.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and Safety of Vonoprazan Triple Therapy in patients with Helicobacter pylori Infection

Systematic review & meta-analysis of randomized controlled trials for H. pylori eradication.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and Safety of Itolizumab for the Treatment of Coronavirus Disease (COVID-19)

Systematic literature review of immunomodulatory interventions during the pandemic.

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Value in Health (IF: 4.9)

Goyal R., et al.

COVID-19 Vaccine Development Pipeline: 2021

Comprehensive mapping of global vaccine development and approval timelines.

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Value in Health Regional Issues (IF: 2.0)

Goyal R., et al.

Current Trends in Covid-19 Testing Rates and Unmet NEEDS

Analysis of global diagnostic capacity and health system bottlenecks.

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Value in Health (IF: 4.9)

Goyal R., et al.

Effect of mobile health interventions on adherence of anti-retroviral therapy in HIV infected patients

Meta-analytic synthesis assessing the efficacy of digital health solutions on medication adherence.

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Value in Health (IF: 4.9)

Goyal R., et al.

Pharmacoeconomic Relevance of Antiretro Viral Therapy (ART) in Low and Middle Income Countries

Health economic evaluation of HIV treatment scale-up in emerging markets.

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Value in Health (IF: 4.9)

Goyal R., et al.

Effect of mobile health interventions on maternal and child health

Systematic review of RCTs evaluating mHealth efficacy in perinatal care.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy and Safety of Teprotumumab in the Treatment of Thyroid Eye Disorder

Systematic review and meta-analysis of targeted biologics in endocrinology.

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Value in Health (IF: 4.9)

Goyal R., et al.

Epidemiology of Eye Disorders Due to the Use of Video Display Terminals in Europe

Systematic literature review of digital eye strain across France, Germany, Italy, Spain, and the UK.

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Value in Health (IF: 4.9)

Goyal R., et al.

Effectiveness of Surface Modified Antimicrobial Implants in Treatment or Prevention of Periprosthetic Joint Infections

Systematic literature review of post-knee replacement surgical outcomes.

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Value in Health (IF: 4.9)

Goyal R., et al.

Efficacy of Surgical versus Non-Surgical Treatment in Carpal Tunnel Syndrome (CTS)

Systematic review comparing long-term outcomes of invasive and conservative interventions.

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Section 03

Project Experience

CONFIDENTIALITY PROTOCOL:
Client and drug names are redacted. Descriptions reflect the scientific and strategic nature of the engagement without exposing proprietary assets.

OncologyNICE (UK)
// Single Technology Appraisal (STA)

Developed the core economic model and global value dossier for a first-in-class targeted therapy. Addressed severe evidence gaps in the control arm through an unanchored matching-adjusted indirect comparison (MAIC), resulting in a positive recommendation.

Rare DiseaseG-BA (Germany)
// Nutzenbewertung Dossier

Led the strategic evidence synthesis for an orphan drug with highly immature overall survival data. Structured the surrogate endpoint validation to meet strict IQWiG methodological requirements, securing added benefit status.

ImmunologyPBAC (Australia)
// Major Submission

Redesigned a failing global Markov model to account for local treatment pathways and specific PBAC pricing constraints. Conducted extensive scenario analyses to isolate the most cost-effective sub-population for restricted listing.

Section 04

Methodology Perspectives

Strategic insights on complex HEOR modeling choices and evidence synthesis.

Opinionated note on the methodological trade-offs when dealing with disconnected networks and small trial populations.

A strategic breakdown of Thailand's HTA body and why simply porting a UK submission will result in failure.

Analysis of why structurally forcing crossing survival curves leads to payer rejection, and how to justify alternative extrapolations.

Working on a submission, a model, or a strategy?
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